Abstract
We report a case of acantholytic squamous cell carcinoma of the mandibular gingiva. A 63-year-old man with a localized indurative mass in the lower gingiva was referred to our department for consultation. Under the clinical diagnosis of carcinoma of the lower gingiva, mandibular segmental resection and neck dissection were performed. Histological and immunohistochemical examinations confirmed the diagnosis of acantholytic squamous cell carcinoma. Metastasis occurred after postoperative radiotherapy, and the patient died of respiratory failure 10 months after surgery.