Localized Mandibular Langerhans Cell Histiocytosis Successfully Treated with Intralesional Corticosteroid Infiltration: A Report of Two Pediatric Cases

Abstract

Langerhans cell histiocytosis （LCH） is an inflammatory neoplasm of myeloid origin characterized by the accumulation of CD1a/CD207 dendritic cells. Recently, the BRAF^V600E mutation has been reported in half of patients with LCH, and BRAF^V600E expression was associated with increased risk of recurrence. This report presents two pediatric cases with LCH affecting the right posterior mandible. Both were successfully treated with intralesional injection of dexamethasone （6mg） in one single session. Complete recovery was confirmed approximately 4-5 years after injection. Intralesional corticosteroid is a less invasive alternative to the classical surgical treatment.