Abstract
Human platelets have effects that not only stop bleeding but also heal wounds. The effect of wound healing depends on many kinds of growth factors in platelets, e.g. PDGF, TGF-β, IGF-Ⅱ.PRP (platelet rich plasma) is the condensation of platelets, so that numerous growth factors are included. Therefore, PRP perform the acceleration of cell growth and healing of the wound rapidly. Recently, there is increased concern in PRP as its function and hearing process relates to bone graft surgery in implant treatment. This article present about the clinical ability of PRP for autologous bone graft, which suffered severe alveolar bone resorption in the maxilla. We performed surgery on 5 patients of which 4 cases of veneer graft in anterior and 2 cases of onlay graft in posterior. Three to four months later, a CT scan was taken, and we examined about the bone volume. Four to five months later, fixtures were implanted, and we took specimens from the bone graft area. In those results, CT images revealed resorption of grafting bone, however, adequate bone remained for the implant. During implant surgery, graft bones were consolidated to original bones completely, and fixtures could be placed according to plan. In microscopic findings, these specimens showed immature tubeculae, which liked weben bone. Despite the short term of wound heal, all cases were successful without infection and wound exposure, and we were able to obtain sufficient bone quantity. In the above mentioned, we knew that PRP was useful for wound healing and bone regeneration without membrane, however, we could not prevent postoperative bone resorption.
