Abstract
It is known that chitosan, extracted from a hard shell, is a biomaterial that is easily decomposed and absorbed in living substances, and it exhibits a lower level of antigenicity. Since chitosan showing alow deacetyl tendency can cause bone resorption,the present study used chitosan with a high deacetyl property, to produce a composite film incorporated with hydroxyapatite (Hap). The pH value of composite films was controlled. After absorbing physiological solution and Ringer's solution into these composite films, animal studies were conducted. The following main conclusions were obtained.
1. The film that had absorbed Ringer's solution exhibited osteogenesis after 8 weeks. These observations can be considered due to the slow-dissolving of the mineral components from the films and dissolving films itself.
2. Hap particles did not migrate from film.
