Abstract
Rickets rat, the bone metabolic disease model, reveals calcification defects. The aim of this study was to observe the bone of the rickets rat using micro-computed tomography (micro-CT) and to examine the bone contact ratio around the sand blasted and anodic oxidation implants. Micro-CT revealed that the femur of the rickets was composed of thin, compact and spongy bones having few trabeculae in comparison with that of the control. At 1 week after the implantation, the bone contact ratio of both implants in the rickets rat was much lower than that of the control. The bone contact ratio of the sand blasted implants (rickets, 9.8±4.4%;control, 76.5±16.5%) was higher than that of the anodic oxidation implants (rickets, 5.2±9.2%;control, 47.2±5.7%) in both the rickets rats and control. Analysis of variance demonstrated a significant difference in all, except for between the sand blasted implants and the anodic oxidation implants of the rickets rats. In conclusion, it was considered that the sand blasted implant could develop more osseointegration than the anodic oxidation implant at 1 week after implantation.
