Abstract
Bone regenetic ability of the periosteum plays an important role in oral surgery and orthopedics, especially in reconstruction after bone loss. Some researchers reported various levels of bone formation experimentally. This discrepancy may be due to a variety of experimental animals and operation techniques employed. For uniting such conditions, we employed SD rats. The purpose of this study is to evaluate the osteogenetic ability of SD rats' periosteum.
In SD rats(8 weeks old), the tibial periosteum was ablated and transplanted onto m. cutaneus trunci under intraperitoneal anesthesia. The transplanted site was examined histologically and radiologically.After 1 week an ectopic new bone formation was observed. It demonstrated a distinct osteogenesis both histologically and radiologically. It was conceived that this phenomenon was not contributed by induction of osteoprogenitor cells, but by bone lining cells derived from inner layer of the periosteum on the basis of scanning electron microgram and roentogenogram.
This results showed that SD rat is an adequate animal model for investigating periosteal bone generation and it can be applied easily to many samples.
