Cytotoxity Study on Shape Memory Ti-Ni Alloy

―Agar Diffusion Method―

Abstract

The Ti-Ni shape memory alloy has favorable biocompatibility. The shape memory alloy exhibit unique deformation behavior such as the shape memory effect.
The authors developed the Shape Memory Implant with excellent effects in clinical use.
However, some reports are presented on the uncertainty of bio-effect ively of Nickel. Therefore,this in-vitro test using cell culture to determine general cytotoxic effects of the Ti-Ni shape memory alloy.
The agar diffusion method was used for cytotoxic screening of this alloy. This in vitro test uses cell culture to determine the cytotoxic effect of sample on discolaration and disintegration.
As a result, there are no detected cytotoxic effects on test samples of Ti-Ni alloy and negative collated sample of pure Titanium.
The cytotoxic effect on pure Nickel was quite modest.
In addition, the positive collated sample of Asbestos strongly indicated cytotoxic effects.