Superselective intra-arterial infusion via the superficial temporal artery and occipital artery combined with daily concurrent radiotherapy for advanced tongue cancer patient with chronic renal failure

—Analysis of platinum pharmacokinetics—

Abstract

We report an advanced tongue cancer patient with chronic renal failure who underwent superselective intra-arterial chemoradiotherapy via the superficial temporal artery and occipital artery.
A 64-year-old woman with ulcer of the tongue was referred to our department. The patient had chronic renal failure, and has been undergoing dialysis three times a week. The mass measured 45 × 40mm and was elastic hard. An incisional biopsy revealed squamous cell carcinoma.
Super-selective intra-arterial chemotherapy using docetaxel (10mg/m²/week, total 50mg/m²) as well as cisplatin (5 mg/m²/day, total 125mg/m²) via the superficial temporal artery and occipital artery combined with daily concurrent radiotherapy (2 Gy/day, total 50Gy,) was employed for five weeks. The treatment course was uneventful and the patient has been free of disease for 16 months.
This method can be one of the effective treatments for oral cancer patients with chronic renal failure.