Abstract
Postoperative chemoradiotherapy with cisplatin in high-risk patients surgically treated for squamous cell carcinoma of the oral cavity was investigated. Of 17 patients studied, 13 patients completed the postoperative chemoradiotherapy, a completion rate of 76.5%. Grade 3 and more severe adverse reactions, as evaluated according to CTCAE Version 4.0, were leucopenia (5 patients), anemia (4), hypokalemia (3), inflammation of the oral mucosa (1), elevated serum creatinine (1), nausea (2), and anorexia (3). The completion rate of postoperative chemoradiotherapy seems to improve as experience with a given regimen accumulates; this therapy regimen was considered fully achievable as a standard therapy. We intend to review therapeutic outcomes in the accumulated cases. It should be possible to develop a new therapy through future studies that use this therapy as a control arm.
