Squamous cell carcinoma of the tongue in a patient with Fanconi anemia treated with surgery and bioradiotherapy: A case report

Abstract

Fanconi anemia （FA） is a rare autosomal recessive genetic disorder characterized by an increased risk of cancer. We report a case of squamous cell carcinoma of the tongue in a patient with FA.
A 23-year-old man was referred to our department with a mass and pain on the left side of the tongue. He had been diagnosed with FA at 3 years of age and had undergone hematopoietic stem cell transplantation at 7 years of age. Clinical examination showed an ulcerated mass measuring 45×18×28mm. He underwent tumor resection with bilateral modified radical neck dissection and reconstruction using a rectus abdominis musculocutaneous flap.
He developed recurrence 4 months postoperatively and underwent salvage surgery. He received bioradiotherapy including cetuximab for recurrence of unresectable disease, 2 months after salvage surgery. He died of progressive recurrent disease 18 months after the primary surgery.