Abstract
We report a case in which nivolumab exhibited a complete response to cervical and distant metastases of tongue cancer. Regular follow-up started after 2 years of administration.
A 70-year-old man underwent surgery, including reconstruction, under the diagnosis of advanced tongue squamous cell carcinoma of T3N2bM0. After the operation, neck recurrence was confirmed. Therefore, we completed simultaneous chemoradiotherapy with cisplatin; however, positron emission tomography–computed tomography （PET–CT） confirmed metastasis to cervical and paratracheal lymph nodes, so nivolumab was selected. The tumor gradually shrank with this drug, and a complete response was diagnosed after 1 year of administration. This drug was administered for 2 years and was then terminated. After 1 year and 4 months, no obvious recurrence or metastasis was observed.
Nivolumab is an expensive drug; however, there is no standard for the administration period. The establishment of a standard for the administration period is awaited, as well as a more careful examination of the therapeutic effects of this drug.
