Abstract
Carcinoma ex pleomorphic adenoma （Ca-ex-PA） mainly arises from the major salivary glands （i.e., parotid gland）, and adenocarcinoma not otherwise specified and salivary duct carcinoma are common histological types. Here, we report a case of a patient with Ca-ex-PA, with myoepithelial cancer derived from the minor salivary glands of the cheek. A 74-year-old woman was admitted to our hospital with swelling of her left cheek. MRI revealed a lobular mass lesion that surrounded the anterior margin of the left masseter muscle. A biopsy revealed the coexistence of malignant components with pleomorphic adenoma, which led to the diagnosis of Ca-ex-PA. Tumor resection and supraomohyoid neck dissection were performed, followed by anterolateral thigh flap transplantation. The patient had a good postoperative course, but about five months after the operation, died from another illness. As Ca-ex-PA is a rare disease in the minor salivary gland, it is desirable to establish preoperative diagnostic methods and treatment strategies by accumulating cases from multiple institutions.
