Clinicopathological features and background factors of multiple oral carcinomas

—12 multiple oral carcinomas with a total 36 foci—

Abstract

The purpose of this study was to reveal the clinicopathological features and the background factors of multiple oral carcinomas. The studies of 12 multiple oral carcinoma patients with a total 36 foci, led to the following conclusions.
1) In terms of sex, siderations are observed more often with females (1 : 5) and their locations were most often on the buccal mucosa and the upper and lower gingivas. Many of them were the granulomatous type and manifested exophytic growth.
2) Second primary tumors were detected in their advanced stage comparatively, however, subseqent tumors were in their early stage. As the number of cancers multiplied, the sideration interval tended to be shortened.
3) As for the background factors, drinking and smoking habits were hardly involved. Rather, the presence of leukoplakia, erythroplakia, lichen planus, Plummer-Vinson syndrome in precancerous lesions and conditions were found to be the risk factors.