A locally advance tongue cancer responding to combination chemotherapy with UFT-E granule and Leucovorin tablet

Abstract

A 68-year-old female had well differentiated squamous cell carcinoma of the left lingual edge (T3N0M0) . UFT-E granule was p. o. administered at a dose of 450mg/day from the first medical examination. The tumor had a tendency to reduce efficaciously. Furthermore, luecovorin tablets were p. o. administered together (30mg/day) in anticipation of tumor reduction for biochemical modulation 3 weeks later. The tumor clinically disappeared, and a partial glossectomy was achieved under general anesthesia. She wore full denture after discharge, and both functions of conversation and swallowing were good. She survived without tumor for 5 years and 2 months.