Abstract
This clinico-statistical study concerns 327 cases of squamous cell carcinoma (SCC) arising from the oral mucosa in the Department of Oral and Maxillof acial Surgery at Kyoto University hospital during the decade from 1990 to 2000. Radical treatment was performed on 286 of these cases.
Our treatment strategy for oral SCC consisted of adequate excision as our first choice for early-stage lesions (T1, early T2), and of combination therapy combining preoperative radiation and surgery for advanced cancers (T3, T4) . In principle, prophylactic neck dissection for early-stage cases and systemic chemotherapy has not been used. The 5-year survival rate was 74.1% overall and 84.3% for the radical treatment group.
The 5-year survival rate was analyzed for the radical treatment group according to stage and primary site classification. The results were as follows, with the number of cases shown in parentheses. Stage I (58) : 98.3%, Stage II (90) : 86.1 %, Stage III (58) : 88.4 %, and Stage IV (80) : 66.6 %; tongue (121) : 84.9 %, lower alveolus and gingiva (60) : 82.6 %, buccal mucosa (42) : 75.5 %, upper alveolus and gingiva (34) : 83.2 %, and floor of the mouth (29) : 92.2 %.
The 40 tumor-related deaths were caused by 11 primary lesions, six cervical metastases, 16 distant metastases, four metastases to the peripheral pharyngeal lymphnodes, two postoperative course, and one course of chemotherapy.
