Abstract
During the 12 years, from January, 1977 to December, 1988, 23 patients with primary squamous cell carcinoma in the mandibular gum visited our Department of Oral Surgery, Dokkyo University Hospital. Their clinical pathology and therapeutic results will be reported.
1. There were 16 male and 7 female patients (male: female=2.29: 1), and the age at the first examination distributed from 39 to 86 years old with 65.0 years old in average.
2. T classification showed 56.5 % of T4, 30.4 % of T2, 8.7% of T1, and 4.3 % T3. N classification showed 52.2 % of N1, 30.4 % of N0, and 8.7 % each of N2 and N3, M classification showed 8.7 % of M1.
3. Absorption of the mandibular bone was found in 13 cases (56.5 %), and the type was erosive in 4 cases and invasive in 9 cases, and the latter showed more extensive absorption.
4. Absorption of the mandibular bone, clinical stage, infiltration pattern, and nuclear DNA pattern were somewhat correlated.
5. 7 cases were treated with single radiation, 4 cases each with single operation, operation+radiation, radiation+chemotherapy, and 2 cases each with operation+chemotherapy, operation +radiation+ chemotherapy.
6. Five-year cumulative survival rate was 43.4 %, and the prognosis seemed likely to be influenced by the degree of tumor growth, and method of therapy.
7. The amount of nuclear DNA at the primary tumor focus was well correlated with the clinical findings and the type of tumor invasion. In the mandibular gum tumor, the nuclear DNA level was a useful index of the degree of malignancy and of the forecast of the prognosis.
