Abstract
Patients with squamous cell carcinoma in the oral cavity were treated with neoadjuvant chemotherapy combined with cisplatin (CDDP) . Eleven cases, which were evaluated as CR, were investivated to histologically assess both biopsy materials, and whole specimens were surgically excised following neo-adjuvant chemotherapy. Histological assessment of preoperative biopsy materials showed 4 cases to be Grade II b and 7 cases to be Grade IV according to the Shimosato's grading system. Moreover, 8 of the 11 cases were closely related to the histological assessment of postoperative serial sections. In CR cases, even though the histological assessment was determined the cases to be Grade II b, tumor remnants were limited to just under the surface of the central portion of the primary tumor. Therefore, reductive excision may be possible in CR cases.
