Abstract
A case of central giant cell granuloma in the mandible of a 10-year-old boy is reported. X-ray examination revealed an unilocular cystic lesion measuring approximately 40X 40mm in the superior portion of the right mandibular ramus. The mandibular ramus was expanded with cortical bone thinning. Giant cell granuloma was suspected according to the bioptic diagnosis. During the biopsy process serous bloody fluid was aspirated by a puncture and hemorrhage was marked, so the lesion was extirpated by an extraoral approach under general anesthesia. The external carotid artery was tied off temporarily. Sherbet-like bone was recognized around the tumor. The tumor was detached easily from the mandible.
Histopathological examination of the extirpated material disclosed that the lesion was composed mainly of fibroblastic spindle cells and multinucleated giant cells. Many fibroblastic spindle cells were arranged in storiform together with the formation of collagen fibers. Relatively numerous multinucleated giant cells existed unevenly. Dilating capillaries were noticed in the mass. In some areas there were reactive osteoid trabeculae surrounded by osteoblasts.
There has been no evidence of recurrence for 7 years and 10 months postoperatively.
