Abstract
Immunohistochemical localization of monoclonal keratin antibodies in monomorphic adenoma (n=5) and pleomorphic adenomas (n=21), including myoepithelioma, were evaluated. Keratin proteins consist of two types; type I keratin consists of K1, 2, 3, 4, 5, 6, 7, and 8 and type II 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, and 20. The presnt study was conducted to evaluate immunoreactivity with MoAb to K4, 7, 8, 10, 13, 17, 18, 19, and 20, KL1, and K 8.12. The intercalated duct cells of normal salivary gland, and the luminal cells of monomorphic adenomas and pleomorphic adenomas showed expression of keratin pairs K8 and K18. Intercalated duct cells in the normal glands are possible pressible precurosr cells of luminal tumor cells of monomorphic and plemorphic adenoma.
