Abstract
In this study, 53 cases with N0 carcinoma of the tongue who received Ra needle interstitial brachytherapy between 1978 and 1994 at Metropolitan Komagome Hospital were used. To study the effect of combined external radiation and combined chemotherapy with Ra needle, 53 cases were divided into 3 groups, the group of Ra needle alone, the group of Ra needle combined with external radiation, the group of Ra needle combined with chemotherapy. Total dose of all interstitial irradiation was 70 Gy, total dose of combined external radiation was 26.1 Gy on average, and CDDP, MTX, and BLM were used for the combined chemotherapy. Incident of secondary neck metastasis, local recurrence and after side effect of radiation were investigated in each group. There were 34 cases in the group of Ra needle alone (T1: 8, T2: 24, T3: 2), 8 cases (T1: 1, T2: 6, T3: 1) in the group of combined with external radiation and 11 cases (T1: 4, T2: 6, T3: 1) in the group of combined with chemotherapy.
As for the result of incident of secondary neck metastasis, 9 cases were found in the Ra needle alone, 1 case in the combined with external radiation, 3 cases in the combined with chemotherapy. It was found that the combined with extranal radiaiton tended to be more effective than other two groups. But as for local reccurence, effect of combined therapies could not be determined. As for side effect of radiation, there were 2 cases in the Ra needle alone group, 2 cases in the combined with external radiation group, and no cases in the combined with chemotherapy. It was considered that the combined with external radiation could be more dangerous than the other two therapies.
