Abstract
We investigated the influence of pre-administered 2% lidocaine with 1: 80,000 adrenalin on infiltration anesthesia by determining the plasma catecholamine concentrations {plasma adrenalin concentration, plasma noradrenalin concentration} and hemodynamic alterations (changes) {systolic blood pressure, diastolic blood pressure, pulse rate} with bolus administration of 4.0ml of 2% lidocaine with 1: 80,000 adrenalin and those with 0.5ml pre-administration prior to 4.0ml bolus administration (of 2% lidocaine with 1: 80,000 adrenalin). The pre-administration time was established (set) at 3, 5 and 7 minutes prior to bolus administration (4.0ml administration). The study subjects enrolled were 32 healthy male volunteers and categorized into 4 groups: Group I was the bolus administration group, Group II was the 3 minute pre-administration group, Group III was the 5 minute pre-administration group and the Group IV was the 7 minute pre-administration group. Results obtained were as follows:
1. The peak plasma adrenalin concentrations in Groups I, II, and IV were recorded at 5 minutes after administration and at 10 minutes for Group III and then gradually decreased thereafter. The plasma concentration of adrenalin was greatest in Group I followed by Groups II, IV and III, respectively.
2. The plasma concentration of noradrenalin revealed a significant increase in Group I at 10, 15 and 20 minutes following administration.
3. Systolic and diastolic blood pressures both revealed (demonstrated) a significant decrease in the study groups in comparison to the control group.
4. The pulse (heart) rate revealed (demonstrated) a significant increase in the study groups in comparison to the control values.
The pre-administration of 2% lidocaine with 1: 80,000 adrenalin prior to bolus administration suppressed the sudden (sharp) increase in plasma adrenalin concentration and in addition, it is speculated (suggested) to prevent the release of endogenous catecholamines by adrenalin.
In addition, it became clear (evident) that the most effective time to administer the bolus administration was 5 minutes following pre-administration.
