ORAL THERAPEUTICS AND PHARMACOLOGY
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
Reports from the Working Group
Report of the committee for establishment of the response evaluation criteria of antifungal therapy for oral candidiasis
Report of the committee for establishment of the response evaluation criteria of antifungal therapy for oral candidiasis
YOICHI NAKAGAWATAKAHIRO ONEYAMAHARUHIKO TERAIAKIHIRO KANEKAWAHIROSHI IWABUCHISATOSHI MIYAKEISAO HASEGAWAMASANORI NISHIKAWAHIDEKI NAKAYAMASATOSHI NISHIMURAJUN-NOSUKE HAYASHIDAKENICHI SAITOKOJIRO ONIZAWAMASAYUKI FUKUDAKANAE NIIMITAKAHIKO SHIBAHARAYOSHINORI JINBUHITOSHI KAWAMATAAKIHISA TSURUMOTOTAZUKO SATOHKATSUNORI ISHIBASHIAKIHIRO KANEKOTAKAHIRO MIYASAKAYOSHIAKI KAMIKAWATOMOARI KURIYAMANOBUKO MAEDASHOJI YAMADATSUTOMU SATOFUMIAKI IKEDAINTETSU KOBAYASHI
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2010 Volume 30 Issue 1 Pages 29-40

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Abstract
Purpose: The purpose of the study was to establish the response evaluation criteria of antifungal agents for oral candidiasis.
Methods: A multicenter open-label trial was conducted. The patients with oral candidiasis were treated by an antifungal agent, itraconazole, and the response to the agent was evaluated according to the protocol. A multiple regression analysis was employed to examine the relative contribution of clinical signs and symptoms, including redness, white papules, atrophy of the papilla of the tongue, pain and soreness to the global evaluation of the responses judged by the attending physician. The global evaluation of the responses was rated as markedly improved, moderately improved or unchanged.
Results: The multiple regression analysis showed that redness of the tongue and palate, white papules on the tongue, atrophy of the papillae of the tongue, and pain were associated with the global evaluation of the responses judged by the attending physician.
Conclusion: Evaluation of these signs and symptoms could provide useful response information about antifungal therapy for oral candidiasis patients. Further studies will therefore be needed to verify the results of the present study.
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© 2010 JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
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