Abstract
We conducted a study assess the bactericidal activity of Sitafloxacin (STFX) against 6 type strain and 1 ATCC strain of main causative organisms of odontogenic infection. Each strain tested was grown in hemosupplemented Brain Heart infusion broth and adjusted to approximately 105 CFU/mL. Test strains were then exposed to 1 × MIC and T-Cmax, antimicrobial tissue level that would be attained with routine antimicrobial administration. Bactericidal activity was measured for up to 8 hours. Against P. intermedia and S. intermedius, bactericidal activity of STFX was shown for up to 8 hours following 1 × MIC.
At T-Cmax, only STFX demonstrated a 3-5 log CFU/mL reduction against P. gingivalis, P. intermedia, S. intermedius and S. gordonii. Furthermore, compared to the other new quinolones tested, only STFX demonstrated rapid and strong bactericidal activity.
Our study shows that when maximum tissue penetration is achieved, with the exception of F. necrophorum, STFX shows strong bactericidal activity against causative organisms of odontogenic infections that it may show the most effective clinical utility including mandibular osteomyelitis and other difficult infections in oral surgery.
