Abstract
We investigated the release behavior of dental drugs by dissolution test in artificial saliva. This knowledge is impotant for judging their medical effects.
The commercial dental drugs studied were nine kinds of troches, five kinds of ointments, four kinds of dental corns and a few others. The dissolution test was modified from the paddle method of JPXI. The dissolution solutions used both artificial saliva I (I) of only inorganic salts and artificial saliva II (II) with inorganic salts and CMC-Na.
The 50% dissolution time of troches at I was 5 min-more than 120min and we found large differences among each of the brands. The dissolution of dental ointments at I could not be observed except for Periocline® and showed the greatest rate of 60% at II. All dental corns were dissolved completely within 30 min at I.
