Influence of combined administration of antacids on the absorption of Lenampicillin (TAKACILLIN^®Tab)

Abstract

In daily clinical practice, antacids have been shown to affect and for interfere with the absorption of antimicrobial agents in many cases. Since Lenampicillin is often used for infection in oral surgery, it is very impotant to study the effects of antacids on Lenampicillin's absorption.
It appears that there is no significance difference of Cmax and AUC of the group given Lenampicillin and the group given Lenampicillin plus antacids. There also seems to be no difference in blood concentration between the two groups, which means that the absorption of Lenampicillin is not affected even by antacids in combined dosage.