Abstract
The interaction of bovine plasma amine oxidase with local anesthetics, procaine and procainamide has been described. The amine oxidase activity was inhibited by both prccaine and procainamide in a mode noncompetitive inhibition when benzylamine and kynuramine were used as substrates. The components of the inhibitors, p-aminobenzoic acid, N, N-diethylaminoethanol and N, N-diethylaminoethylamine which could be produced by the enzyme-catalyzed hydrolysis of the inhibitors in serum failed to exert any effects on the amine oxidase reaction.
