Abstract
The blood concentration of CFDN in wound after tooth extraction and oral tissues after single adiministration with 100mg were determined, and the results were obtained as follow:
1. CFDN was administered to a total of 153 patients before exraction, and 164 specimens were collected. When the concentration was set at MICs of oral streptococci (0.2μg/ml) or Peptostreptococcus spp. (0.1μg/ml) as a target level, 39 in the 164 samples (23.8 %) achieved over 0.2μg/ml and 73 (44.5 %) over 0.1μg/ml.
2. The penetration of CFDN into oral tissues was determined in 15 patients. The concen-tration in gingiva ranged from <0.016 (under the measurable limit) to 0.959μg/ml in 14 patients, mean ± S.D. value was 0.282±0.272pg/g in 11 patients excepted three (<0.016μg/g) from all 14 patients.
The concentration in cyst wall ranged from 0.088 to 0.519μg/g, being 0.367+0.200μg/g in average. The transfer ratio of gingiva tissues to the serum ranged from 0.66 to 1.99, and its ratio of cyst wall ranged from 0.27 to 1.05, with good penetration.
From the above results, concentration of CFDN in wound after tooth extraction was somewhat low, but good penetration into oral tissues was obtained.
