Abstract
Flomoxef (FMOX) of 1 g was administered to 29 patients respectively by intravenous bolus injection. The distribution to oral tissues of FMOX and the pharmacokinetic analysis of the maxillary and mandibular bones were performed.
The following results were obtained.
1) The concentrations of FMOX in the serum were 57.6μg/ml, 36.7μg/ml, 18.4μg/ml, 7.70μg/ml, 1.97μg/ml and 0.50μg/ml at 15 minutes, 30 minutes, 60 minutes, 120 minutes, 240 minutes and 360 minutes after injection, respectively. T1/2 (β) was 1.04 hour, and AUC was 66.8μg⋅hr/ml.
2) The concentrations of FMOX in the maxillary and mandibular bones were 6.07μg/g, 5.15μg/g, 2.59μg/g, 0.98μg/g and 0.25μg/g at 15 minutes, 30 minutes, 60 minutes, 120 minutes and 240 minutes after injection, respectively, and ranged from 10 to 14% of the serum level. T1/2 was 0.28 hour, and Cmax was 6.10μg/g.
3) The concentrations of FMOX in the cyst wall, gingiva and nasal mucosa ranged from 30 to 90% of the serum level.
