Abstract
The quantity of non-steroidal anti-inflammatory drugs (NSAIDs) and anti-inflammatory enzymatic drugs used at 29 Japanese dental hospitals was investigated using questionnaires.
Of the 29 hospitals, 11 were affiliated with national universities, 17 were affiliated with private dental colleges or universities and one was affiliated with a public dental college.
The three NSAIDs dispensed mostly over a 10-day period and purchased mostly over a 6-month period and evaluated during 1992 were loxoprophen sodium, diclofenac sodium and mefenamic acid.
Rated by chemical structure, the drugs classified as propionates (Loxonin®, Orudis®, Froben®, Niflan®, Brufen®, Minalfen®) had highest use (46.9%) while allyle acetates (Voltaren®, Docell®, Fenazox®, Infree®, Indacin®, Inteban®, Clinoril®) were next at 32.3%.
There was little variation found among the hospitals in the use and purchase of the anti-inflammatory enzymatic drugs.
The three drugs dispensed mostly over a 10-day period were, in order, 30 mg lysozyme chloride, 5mg serrapeptase and 9000 IU pronase.
The anti-inflammatory enzymatic drugs purchased mostly over a 6-month period were, in order, 5mg serrapeptase, 30 mg lysozyme chloride and 50 mg lysozyme chloride.
Although the combined use of two NSAIDs is contraindicated due to side effects, such a combined use was observed in few hospitals.
