Abstract
The experimental models in the mandibule of New Zealand White rabbits infected according to the Satoh-Heimdahl method were administered new oral cephems, cefcamate pivoxil (CCMT-PI) and cefpodoxime proxetil (CPDX-PR), at a dose of 20mg/kg, The transfer into serum, oral tissues, tongue, gingiva, submandibular gland, parotid gland, submandibular lymph node, jaw bone, and pus were examined and studied accordins to pharmacokinetics.
After administration of CCMT-PI, Tmax was 0.75 hour, and Cmax of CCMT in serum was 3.98μg/ml. Tmax's of the examined tissues were 0.75-1.0 hr and Cmax's were 3.14-5.48μg/g, thus the tissue to blood concentration ratios were 0.79-1.38 in the infected group. Furthermore, Tmax, Cmax, and the tissue to blood concentration ratio of CCMT were 1.0 hr, 3.66pg/ml, and 0.92 in the pus.
With regard to CPDX-PR in the infected group, Tmax in serum was 1.0 hr, after adminis-tration and Cmax reached an extremely high concentration, 14.89μg/ml.
Tmax's of the examined tissues of CPDX were 1.0 hr, Cmax's were 3.60-13.48ug/g, and the tissue to blood concentration ratios were 0.24-0.91 in the infected group. Also Tmax, Cmax, and the tissue to blood concentration ratio of CPDX were 1.0 hr, 5.18ug/ml, and 0.35 in the pus.
Moreover, CCMT-PI and CPDX-PR achieved good concentrations in the oral tissues and the pus in the infected lesion of the rabbits.
