Effusion level of tooth extraction wound and gingival crevicular fluid level after oral administration of Sparfloxacin (SPFX)

Abstract

Oral dose of 200 mg Sparfloxacin (SPFX) was administrated before exodontia was performed on 70 patients. The drug concentration of Sparfloxacin in the effusion from the tooth extraction wound was measured from 615 to 1090 minutes after peroral administration. And in 7 cases, the drug concentration in the gingival crevicular fluid was measured.
In SPFX, it has been recognized that 80 % of MIC against Oral Streptococci was 0.39 μg/ml. SPFX was valued≥0.39μg/ml in 61 out of 70 cases (87.1 %) in the effusion from the tooth extraction wound and in all cases in the gingival crevicular fluid.