Abstract
Prophylactic effectiveness of antimicrobial regimens on postoperative infection in oral surgery were evaluated in 65 patients. One out of five antimicrobial agents (ABPC, CEZ, CTM, CMZ and FMOX) was selected and administered just before surgery. Duration of administration of the antimicrobial agent was classified as one of three patterns (1 day, 4 days or 7 days) according to operative cleanliness, operative damage and protective ability against infection. Each antimicrobial agent was administered by intravenous 1 hr drip infusion every 4-6 hours on operation day, and the administration was continued postoperatively at a dose of lg (except for 2g in ABPC) every 8 hours or twice a day on the following days. No oral antimicrobial agents were administered during this period.
The results were as follows :
1) On our criteria for regimen, a four-day administration schedule was chosen for most of the cases (57/65) .
2) The rate of postoperative infection was 3.1% (2/65, mild) .
3) As side effects, elevation of s-GOT and s-GPT in 5 cases was observed and mild diarrhea in some cases was observed. However, it could not be judged whether they were regarded as side effects because they all had received nutrition.
Based on the present results, our regimen seems to be safe and quite useful for preventing postoperative infection in oral surgery.
