Abstract
Oral dose of 200mg sparfloxacin (SPFX) was administered before exodontia to 94 patients. The drug concentration of sparfloxacin in the effusion from the exodontia wound was measured from 615 to 1097 minutes after preoral administration. In 31 cases, the drug concentration in the gingival crevicular fluid was measured.
SPFX has been recognized that 80% of MIC against Oral Streptococci was 0.39μg/ml. SPFX valued ≥0.39μg/ml in 73 cases out of 94 cases (77.7%) in the effusion from exodontia wound and valued ≥0.59μg/ml in all cases in the gingival crevicular fluid.
