Abstract
For prophylactic use of ceftriaxone intravenously, twenty blood samples after tooth extraction were cultured on Bactec NR 16 A® and NR 17 A® (Becton Dickinson, Maryland, U. S. A.) . Each MIC of ceftriaxone in identified microbes was measured. In addition the serum concentrations of ceftriaxone were measured. The incidence of bacteremia was 15 % (3 out of 20) and three strains were isolated. They were all anaerobes, and no streptococcal bacteremia were detected. The MICs of ceftriaxone were 0.39, 1.56 and 12.5 μg/ml. The serum levels varied from 95 to 277 μg/ml, which were satisfactory concentrations. The results suggested that intravenous ceftriaxone prophylaxis for tooth extraction decreased Bacteremia rates significantly, including the isolated rate of streptococci.
