Clinical evaluation of allopurinol mouthwash for mucositis induced by cancer chemo- and radiotherapy

Abstract

A study was carried out to evaluate the efficacy of allopurinol mouthwash on mucositis induced by chemotherapy or/and radiotherapy in patients with oral cancer. The effect of allopurinol mouthwash was judged according to the World Health Organization grading system. Eight of the nine patients (89%) were reduced clinical status on mucositis. Treatment with allopurinol mouthwash was well tolerated in all patients. There were no adverse effects in trial of allopurinol mouthwash. Allopurinol mouthwash was considerably effective against mucositis induced by chemo- and radiotherapy.