Abstract
The purpose of the present study was to elucidate the acute toxicity in mice of a new dentin primer, the oxalates solution (a proprietary mixture of aqueous solutions of potassium and aluminum oxalate), which brings about more effective bonding of the new mechanism to composite resin and dentin, and was considered to cause little adverse reaction of treated teeth such as dentin fragility and pulp lesion.
Five mice were administered orally the test substance in a single dose of 10ml/kg, and submitted to general observation for 14 days. Purified and sterilized water was given to mice of the control group.
During the observation period, neither death nor toxic symtom occurred in mice of either group, their appearance was good and they showed quite normal behavior. The subjects had a normal growth curve, and there was no significant difference (p>0.05) between the groups as to weight gain and food and water intake. At the termination of 14-day observation, all the mice were sacrificed. After postmortem examination, hematological and histopathological examinations were performed and it was clarified that there were no anomalous findings in the test group in comparison with control group.
The results suggested that acute toxicity of the new primer is markedly slight even in man, and that it is practically non-toxic especially in such a small dose as used for dental treatment.
