Abstract
Morishima and Sasaki reported that without the chemoprophylaxis of antimicrobial agents, 69.2% of blood culture was positive when the blood sample was collected from the vein immediately after tooth extraction. Recently, the incidence of transient bacteremia has been studied with the chemoprophylactic use of antimicrobial agents. In the present study, three kinds of medium (Bactec®, FAN®, VITAL ANA®) were compared and the experiment was conducted with imipenem (IPM) for chemoprophylaxis. Intravenous drip infusion of IPM was started before the operation, which took about 30 minutes. Within 5 minutes after the completion of the drip infusion and while the surgical procedure was underway, the venous blood was collected.
The blood sample, after part of it was set aside for the measurement of the IPM concentration, was placed on Bactec®, FAN®, and VITAL ANA®.
The culture positive rates of three media, Bactec® containing neutralizer, FAN® containing neutralizer, and VITAL ANA® which doses not contain neutralizer, were compared. Bactec® and FAN® had 2 culture positive cases out of 12 cases, but the blood cultures of VITAL ANA® were all negative. The MICs of IPM in the culture positive cases were high enouch to inhibit the growth of organisms. While investigating transient bacteremia immediately after dental surgery, if media did not contain neutralizer, administered agents were considered to work so as to make results false negative.
