Abstract
Rabbit jaw bone infection models were used to study the penetration of antimicrobials in the blood and tissues. In this pharmacodynamic analysis, aspoxicillin (ASPC), a penicillin, and panipenem/betamipron (PAPM/BP), a carbapenem, were selected as test drugs. Jaw bone infection was induced by the Satoh-Heimdahl method. ASPC (20mg/kg) and PAPM/BP (20mg/ 20mg/kg) were administered intravenously for 30 minutes to the rabbit jaw bone infection models. Healthy rabbits, prepared as controls, were placed on the same antimicrobial therapy and the results were compared. Serum and pus samples and the specimens obtained from upper and lower jaw bones, trachea, and ilium were measured.
1) Serum and tissue penetration rates of antimicrobials were higher in the infection models than in the controls. This phenomenon was observed in both the ASPC and PAPM/ BP administration groups.
2) ASPC and PAPM/BP penetrated into the hard tissues of upper and lower jaw bones and ilium at nearly the same rate. Compared with other tissue specimens, the tissue specimen obtained from the trachea showed a much higher antimicrobial penetration rate.
