Abstract
The transfer of cefpirome (CPR), a cephem antibiotic, into human serum and oral tissues after intravenous administration of CPR at a dose of 0.5g or 1.0g was studied in 20 patients, consisting of 11 males and 9 females. The results were as follows:
1. The concentrations of CPR in the serum showed dose dependence. The serum half-life in each case was 2.01 hours. The AUC of CPR 0.5 g and 1.0 g were 128.9μg⋅ml/hr and 254.9μg⋅ml/hr respectively.
2. The ratios of oral tissues to serum concentrations ranged from 6.81-79.0 % during 1-2 hours after administration of CPR.
The transfer of CPR to oral tissues was demonstrated to be favorable and no abnormal findings were observed. CPR is expected to be useful for oral infections.
