Abstract
Polymorphonuclear leukocytes (PMNs) were isolated from the mandible infection models in NZW rabbits. The effects of new quinolones on their migration were evaluated. New quinolones were ofloxacin (OFLX), lomefloxacin (LFLX), tosufloxacintosilate (TFLX), fleroxacin (FLRX), sparfloxacin (SPFX), and levofloxacin (LVFX), which are now used in the field of clinical dentistry. The results were as follows:
1) In the inoculation group, those that received no antimicrobial therapy showed an acceleration of PMN migration. This phenomenon observed three and seven days after inoculation was more significant than that observed before inoculation.
2) When no antimicrobials were administered PMN migration observed in the inoculation group was different from that observed in the control group. The levels of acceleration of PMN migration measured three and seven days after inoculation were 1.16 and 1, 10 times more significant than those measured in the control group.
3) The six antimicrobials were administered in various concentrations to evaluate their effects on PMN migration before inoculation OFLX in the concentration of 1μg/ml rarely affected PMN migration and that in the concentration of 10μg/ml accelerated PMN migration remarkably. OFLX in the high concentration of 100μg/ml significantly inhibited PMN migration. Similar tendencies were observed in the experiments using the remaining five antimicrobials.
