Abstract
Twenty-two blood samples after tooth extraction with administration of clindamycin-2-phosphate intravenously were cultured with Bactec NR16A® and NR17A® (Becton Dickinson, Maryland, U. S. A.) . The strains were identified and each MIC of clindamycin was measured, and the serum concentrations of clindamycin were determined. The incidence rate of bacteremia in 12 cases out of 22 rated 54.5 %. Fifteen strains were isolated from 12 patients ; 7 were aerobic and 8 were anaerobic. MICs of clindamycin for isolated organisms were under 0.20μ g/ml. The serum levels of clindamycin were ≥2.88μg/ml, and the concentration was sufficient for each isolate.
The AHA (American Heart Association) and BSAC (the Endocarditis Working Party of the British Society for Antimicrobial Chemotherapy) recommend the use of clindamycin as prophylaxis of post tooth extraction for the patients who are allergic to penicillin. However, these results reveal that clindamycin is insufficient for the prevention of transient bacteremia after tooth extraction. It is suggested that the bactericidal activity of clindamycin is insufficient in a short time.
