Concentration of cefcapene pivoxil hydrochloride (CFPN-PI, Flomox^®) in serum and in synovial fluid of temporomandibular joint with temporomandibular joint disorder

Abstract

The tissue concentration of an ester-type oral cephem antibiotic, cefcapene pivoxil hydrochloride (CFPN-PI, Flomox^®), was investigated in patients with temporomandibular joint disorder (TMD) . The results were as follows :
1. The peak concentration of CFPN in serum was 17.2μg/ml after oral administration of CFPN-PI 200mg. The peak concentration in synovial fluid of temporomandibular joint (TMJ) was 0.45μg/ml. The peak level in serum was 3.8-fold that of the peak level in synovial fluid.
2. The rate of transfer of CFPN from serum to synovial fluid of TMJ after oral administration was 12.1-74.0%.
3. Adverse reaction was slight diarrhea in one case.
Based on the above, CFPN-PI is considered to be useful for TMD patients with surgical infection.