Pharmacokinetic study of one dose of 750mg of Amoxicillin

Abstract

We studied the prevention of bacterial endocarditis, lowering the incidence of transient bacteremia by administering antimicrobial agents prior to tooth extractions. In Japan, the regimen recommends oral administration of amoxicillin (AMPC) to moderate-risk patients.
In the present study, one dose of 750mg of amoxicillin was administered orally to four healthy volunteers. Afterward, blood concentrations of the drugs were measured by bioassay. A pharamacokinetic study was performed using one compartment model.