Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of medications worldwide. Diclofenac sodium is a kind of NSAIDs advocated for use in dental medicine. It is also well known to prevent osteoporosis in postmenopausal females. The purpose of the present study was to investigate the possible inhibitory effect on osteoclastogenesis in the presence of diclofenac sodium. Nonadherent Sephadex G10-passed bone marrow cells were cultured in a-MEM containing the final concentration of 15% FBS, 60ng/mL RANKL, 20ng/mL CSF-1 for 6 days. Treatment with diclofenac sodium blocked osteoclastogenesis in vitro dose-dependently. The results suggested that diclofenac sodium may act on the precursor of osteoclast directly to prevent osteoporosis.
