Abstract
We performed preoperative combined therapy using nedaplatin (CDGP) and radiation on 25 patients with squamous cell carcinoma originating from the oral cavity and maxillary sinus, and examined any adverse events that occurred during this therapeutic regimen. Regarding the irradiation, external irradiation utilizing a 6 MV linac (linear accelerator), at a dose of 2.OGy/day, was performed 5 times a week, with the target total radiation dose set at 4OGy. In addition, CDGP was intravenously administered 30 minutes before irradiation, at a dose of 5 mg/m2/day.
Mucositis was observed in all 25 subjects; however, the severity was observed to be grade 1-2, with no major differences compared with the patients given standard radiation monotherapy. Six subjects developed grade-3 leucopenia. Three subjects were thus given granulocyte colony stimulating factor (G-CSF) .
Grade-2 thrombocytopenia was observed in two, and grade-3 in three, subjects. The subject with grade-3 thrombocytopenia required a platelet transfusion during surgery. No marked changes in serum creatinine levels were noted. These findings are considered to provide evidence supporting safety of this combination therapy.
