Suppressive Ability of Anti-inflammatory Agents on PGE₂ Production in Carrageenin-induced Inflammation in the Buccal Region of Rabbits

Abstract

Concentrations of aspirin and its metabolite: salicylic acid, were investigated using a microdialysis method in carrageenin-induced inflammatory lesions in the buccal region of rabbits, and the abilities of these agents to suppress PGE₂production were determined.
Compared with control levels, the PGE₂concentration in the inflammatory lesions was significantly lower at from 3 to 24 hors following aspirin administration.
The concentration of aspirin in the inflammatory lesions peaked at 20 minutes after administration, and dropped below the detection limit at 120 minutes after administration, whereas the concentration of salicylic acid peaked at 5 hours after administration, and some salicylic acid was still detectable at 24 hours after administration. Concentrations of both aspirin and salicylic acid in the blood were greater than those of the respective inflammatory lesions.
These findings suggest that aspirin and its metabolite: salicylic acid, suppress the production of PGE₂in inflammatory lesions for 24 hours after administration.