Abstract
Levofloxacin (LVFX) concentrations in human serum, gingiva, mandibular bone, and dental follicle following a single oral administration of LVFX (200mg) were studied. The mean concentrations in serum, gingiva, mandibular bone, and dental follicle peaked at identical times, 1.5 h after administration, and were 2.29 μg/mL, 2.70, 1.33, and 2.46 μg/g, respectively. The mean concentration ratios of gingiva/serum, mandibular bone/serum, and dental follicle/serum at the peak time were 1.17, 0.60, and 1.13, respectively. Seventy percent of the LVFX concentrations in gingiva and dental follicle exceeded the MIC for 90% of clinically isolated strains of oral streptococci, but most of the LVFX concentrations in mandibular bone (4/5) did not exceed the MIC for 90% of clinically isolated strains of oral streptococci. The present results were obtained after a single dose study, however, higher concentrations of LVFX in oral tissues would be obtained after a multiple dose schedule.
