Abstract
Cefditoren (CDTR) concentrations in human serum, gingiva, mandibular bone, and dental follicle following a single oral administration of cefditoren pivoxil (CDTR-PI) (200 mg) were studied. The mean concentrations in serum, gingiva, mandibular bone, and dental follicles peaked at identical times, 2 hours after administration, and were 1.89μg/mL, 0.76, 0.38, and 0.77μg/g, respectively. The mean concentration ratios of gingiva/serum, mandibular bone serum, and dental follicles/serum at the peak time were 0.43, 0.21, and 0.41, respectively. Most of the CDTR concentrations in gingiva, mandibular bone, and dental follicles exceeded the MIC for 80% of clinically isolated strains of oral streptococci. Thus, CDTR-PI may be a valuable antimicrobial agent for the treatment of odontogenic infection.
