Abstract
The therapeutic regimen of Ofloxacin in odontogenic infection and in chemoprophylaxis of exodontia was studied. The reliability of therapeutic drug monitoring of salivary drug concentration was also examined.
The following results were obtained.
1) Normal meal intake had almost no effect on the absorption of orally administered Ofloxacin. However, when administered after taking a high calorie meal, delay of Tmax and decrease in Cmax were observed.
2) When an oral dose of 200 mg Ofloxacin was administered before exodontia, drug concentration in the blood from the operative region as well as in saliva was sufficient to expect chemoprophylaxis.
3) Saliva and blood concentrations of Ofloxacin were almost equal after oral intake of the drug, indicating that the saliva concentration could be depended on for therapeutic drug monitoring.
