Abstract
We studied Enoxacin (ENX), a new-quinolon antibacterial agent, by comparing the drug concentration in tooth extraction wound blood with general concentration of the drug. The measurements were performed in 48 healthy volunteers 1, 2, 3, 4 and 6 hours after the drug was administered. The mean concentration in the tooth extraction wound blood and general concentration of ENX reached a peak after one hour. The drug concentration in the tooth extraction wound correlated well with the general blood concentration with a coefficient of correlation of 0.86. The drug was well accessed into the tooth extraction wound with a wound/blood concentration ratio of 1.323.
